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KMID : 0923620090090050169
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Immune Network
2009 Volume.9 No. 5 p.169 ~ p.178
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Enhancement of DNA Vaccine-induced Immune Responses by Influenza Virus NP Gene
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Choi So-Young
Sung Young-Chul
Suh You-Suk
Cho Jae-Ho
Jin Hyun-Tak
Chang Jun
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Abstract
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DNA immunization induces B and T cell responses to various pathogens and tumors. However, these responses are known to be relatively weak and often transient. Thus, novel strategies are necessary for enhancing immune responses induced by DNA immunization. Here, we demonstrated that co-immunization of influenza virus nucleoprotein (NP) gene significantly enhances humoral and cell-mediated responses to codelivered antigens in mice. We also found that NP DNA coimmunization augments in vivo proliferation of adoptively transferred antigen-specific CD4 and CD8 T cells, which enhanced protective immunity against tumor challenge. Our results suggest that NP DNA can serve as a novel genetic adjuvant in cocktail DNA vaccination.
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KEYWORD
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DNA vaccine, influenza virus NP, adjuvant
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